Transparent clinical logic

Curated evidence library

Each pattern shows the observed medication sequence, expected onset window, confidence logic, source references, and a non-directive conversation prompt.

Documented pattern

Calcium-channel blocker edema → loop diuretic

2–12 weeks after initiation or dose increase

A diuretic can be added to treat dose-related ankle edema from a dihydropyridine calcium-channel blocker, even though the edema is not primarily volume-mediated.

Amlodipine→Furosemide

2 source references

Documented pattern

Donepezil diarrhea → loperamide

Days to 8 weeks after initiation or titration

Cholinergic gastrointestinal adverse effects may be managed with an antidiarrheal rather than revisiting dose, titration rate, or treatment goals.

Donepezil→Loperamide

2 source references

Documented pattern

Cholinesterase inhibitor incontinence → antimuscarinic

1–16 weeks after initiation or titration

Treatment for urinary symptoms can oppose the intended cholinergic effect of dementia therapy and add anticholinergic burden.

Rivastigmine→Oxybutynin

2 source references

Documented pattern

ACE inhibitor cough → antitussive

1 week to 6 months after initiation

A persistent ACE inhibitor cough may prompt symptom treatment instead of a review of the antihypertensive regimen.

Lisinopril→Benzonatate

2 source references

How to read this library

Patterns flag a plausible sequence, not causality. Confidence is driven by chronology, symptom documentation, and competing explanations—not a hidden model score.

CascadeGuard prototype · Synthetic medication timelines only · DEMO DATA — NOT FOR REAL PATIENT USE
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